Life without drugs
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We live in difficult times (though when was it easy?). In the context of ever-increasing pressure and sanctions from the West, Russia is going through a difficult period of abandoning the euphoria of “friendship” with him. Having believed the promises of the globalists, the principles of the global division of labor and free trade, Russia has reduced or completely destroyed a number of industries, including the development and production of medicines. Now we have to urgently restore all this, which is difficult, long and expensive under the sanctions.
In addition, drug medicine combined with the health care business model is a dead end. The more tests, procedures (better than surgical, they are more expensive) and prescriptions, the richer the manufacturers of goods for medicine, hospitals, clinics, test laboratories and doctors become. Society is not getting healthier, and health care costs are on the rise. The development of new drugs costs billions of dollars, which are then collected from patients. It becomes clear why cheap medicines disappear from the market, and doctors recommend new, more expensive ones, why they do not replace, but add new drugs to those already prescribed, and why they treat the symptoms, not the causes of diseases. What to do?
Maybe we need to stop trailing behind the West and turn to our own traditions of traditional medicine, a healthy lifestyle, nutrition, breathing, physiotherapy and spa treatment, as well as modern developments in the field of medicine.
In this article, we will talk about the little-known work of the Russian scientist Valentin Shilov, who developed the theory of regulation of structural processes in tissues and skin. This theory allows to explain from a unified position the causes of a number of age-related diseases, such as atherosclerosis, hypertension, coronary heart disease (CHD), obesity and diabetes. There was also an opportunity to solve the problem of psoriasis and understand the mechanisms of the inflammatory process (see the articles “Psoriasis – a mistake of nature or a reward of humanity?” 06/26/2022 and “Is inflammation normal?” 08/01/2022). It is clear that understanding the mechanisms and patterns of the course allows us to offer fundamentally new methods for diagnosing and treating these diseases.
Atherosclerosis, hypertension, coronary heart disease, obesity and diabetes are typical representatives of the so-called multifactorial diseases, in the development of which countless risk factors have been identified, and many factors are common to this group of diseases. Thus, about 250 such factors have been identified for atherosclerosis. Such an abundance of causes usually indicates a lack of understanding of the underlying mechanisms underlying the development of these diseases.
How the body manages cell life
The emergence of multicellular organisms and their adaptation to life in an oxygen atmosphere posed many problems. First of all, these are the tasks of controlling cellular and tissue ensembles, since each individual cell tends to uncontrolled reproduction. The most ancient control levers are the flows of energy substrates and oxygen. Cell division is regulated by glucose transport, as it stimulates cell division, and oxygen transport, which suppresses it (Fig. 1).
Rice. 1. Regulation of division and functional activity.
Glucose entry into cells is controlled by insulin, hormones and growth factors, and several transport proteins for different tissues. Most cells, in conditions of oxygen availability, are able to switch to a more efficient way of producing energy (almost 20 times more ATP molecules per 1 glucose molecule) (an effect discovered by Pasteur in 1857.). Therefore, the Pasteur effect can be considered as an intracellular switch of the modes of functional activity of cells.
The energy supply of the nervous system is also carried out at the expense of glucose, so the level of glucose in the blood is maintained at a certain level for the efficient functioning of the brain. Excess glucose is stored “for a rainy day” in the form of glycogen (mainly in the cells of the liver and muscles) and fats. Insulin is the stimulator of these processes.
Changing living conditions, progress and disease
The mechanisms of regulation of cell proliferative activity were formed at a time when the satisfaction of hunger was associated with considerable effort. Under such conditions, it was necessary not only to make the most of the resources received, but also to save their excess for later use. At the same time, the body solved the problem of inhibiting cell division, since excess glucose was temporarily removed from circulation.
However, in the conditions of modern society, with its emotionally stressful nature of life, the availability and abundance of food, overeating and physical inactivity lead to an excess of energy substrates and a lack of oxygen supply to tissues. As we age, these problems only get worse. The key factor in reducing the adaptive capacity of the body with age is the change in the intercellular substance, which limits the diffusion of oxygen into cells. All of the above factors cause a shift in the redox potential of tissues in the direction of recovery and create conditions for excessive cell division (Fig. 2). And this is associated with the risk of cancer.
Picture. 2. Influence of risk factors on the ability of tissues to divide.
The compensatory reaction of the body to the current situation is quite normal. Depending on the genetic characteristics of the individual and his lifestyle, the body can restore the oxygen supply to tissues due to a systemic increase in blood pressure. It is also possible to provide resistance to insulin to cells capable of dividing, and the forced removal of excess glucose from the body. The first way out of the crisis is fraught with the risk of developing hypertension, damage to the main vessels (atherosclerosis) and the development of coronary heart disease (CHD), and the second can lead to the development of non-insulin dependent diabetes mellitus (NIDDM). If the body uses both methods of protection, several pathologies can occur together in a person.
Thus, the mechanisms of protection of cells from unauthorized reproduction under conditions of risk factors, instead of stabilizing the situation, on the contrary, can provoke the development of the disease.
What recommendations can be made from the new concept
The fact that the mechanisms of cell defense are also mechanisms for the development of the disease, allows us to hope that the body has every opportunity to restore its normal state. And understanding the mechanisms makes it possible to purposefully control and help patients with these pathologies. Moreover, the commonality of causes implies a commonality of approaches to their non-drug correction.
1) Exclusion of risk factors: overeating, excess weight, smoking and alcohol consumption, excessive exercise and stress.
Obesity increases the load on the cardiovascular system and causes a lot of complications. Therefore, it is so important to control your weight, not overeat and alternate periods of nutrition with periods of hunger strike. During fasting, the body not only gets rid of toxins, excess reserves, damaged cells, but also reorganizes itself into more efficient modes of functioning. The stomach, stretched from overeating, contracts, which reduces appetite and food is absorbed more fully. Systems of auto-training, meditation and relaxation help to cope with stress.
2) Restoration of tissue oxygen supply.
Many methods have been tested for centuries, there are also new developments based on the data of modern science. Here is a deliberately incomplete list of systems that are consistent with the stated concept of regulation of tissue homeostasis: various respiratory systems – yoga, meditation, K.P. Buteyko. It would seem that the less often we breathe, the less oxygen enters the body, but this is not so. The accumulation of carbon dioxide leads to relaxation of blood vessels and improvement of microcirculation, which in turn increases oxygen delivery. A.A. systems Mikulin and I.P. Neumyvakina help the heart cope with stress, and the latter also regulates blood parameters.
3) Changing modes of tissue oxygenation.
To ensure intensive functional activity, a high level of oxygen saturation of tissues is required, and a low level is required for the processes of growth and structural renewal of tissues. Therefore, a change in oxygenation regimes that shift the redox (redox) potential of tissues is a necessary condition for their structural reorganization when functional activity is minimal. In this regard, vigorous activity and the processes of growth and structural renewal of tissues are “separated” in time and correspond to periods of wakefulness and sleep. This is the concept of V.N. Shilova supplements the visceral theory of sleep by I.N. Pigarev.
4) Maintaining a certain, moderate level of adaptation, in which the increased requirements of the environment are calmly satisfied. Such adaptation to physical stress not only increases the body’s performance, but also increases its resistance to hypoxia, inhibits the development of atherosclerosis, hypertension and diabetes. That is, moderate exercise and a reasonable alternation of work and rest is the key to health. On the contrary, both excessive loads and physical inactivity and laziness sharply increase the generation of reactive oxygen species and, accordingly, the available proliferative potential of tissues is rapidly consumed, which reduces the life span allotted to us by nature. An analogy with shagreen leather from the novel of the same name by Honore de Balzac suggests itself (Fig. 3).
Picture. 3.
Why do many patients still prefer drugs? There are several reasons: 1) inability (unwillingness) to change lifestyle and habits; 2) laziness – it is easier to take a pill than to do exercises; 3) pressure of doctors on patients and pharmaceutical companies on doctors; 4) the capitalist approach to medicine as a business (service sector), the doctor as a seller of services, and the patient as their buyer. Let’s hope that the sanctions will help Russia find the right path.
Sergey Geodakyan, Candidate of Medical Sciences, graduate of the IBF (physician-biophysicist) Russian National Research Medical University named after N.I. N. I. Pirogov.
Other articles by the author
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